The POLA2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to POLA2. This antibody recognizes Human antigen. The POLA2 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Function: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
Subunit Structure: DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A.
Post-translational Modifications: Phosphorylated in a cell cycle-dependent manner, in G2/M phase.
Similarity: The N-terminal 240 amino acids are sufficient to mediate complex formation. Belongs to the DNA polymerase alpha subunit B family